William A Friedman

William A Friedman, M.D.

Professor

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 271-9000

About William A Friedman

Dr. William Alan Friedman was born in Dayton, Ohio on April 25, 1953. He attended high school in Cincinnati, Ohio. He graduated in 1970 as a National Merit Scholar and attended Oberlin College. There he was elected to Phi Beta Kappa before moving on to the Ohio State University College of Medicine. Before graduating summa cum laude from medical school in 1976, he was elected to the Alpha Omega Alpha honor society and received the Maurice B. Rusoff Award for excellence in medicine. In 1976, Dr. Friedman moved to the University of Florida in Gainesville, Florida. He performed a surgical internship and a neurosurgical residency, from which he graduated in 1982. During residency training he did basic neurophysiology research as an NIH postdoctoral fellow (1 F32 NS0682-02). In 1982, he joined the faculty of the Department of Neurosurgery, as an Assistant Professor. He received an NIH Teacher Investigator Award (NS 00682-02), from July, 1982 – July, 1987, which funded further research into the basic neurophysiology of spinal cord injuries. In addition, this award supported the development of one of the first intraoperative neurophysiology monitoring laboratories, subsequently used to monitor thousands of neurosurgical and orthopedic surgical cases. Dr. Friedman served as Medical Director of the Intraoperative Neurophysiology Service from 1982-1992. Dr. Friedman was promoted to Associate Professor and received tenure in August, 1987. In August, 1991 he was promoted to Professor. In 1999, he became Chairman of the Department of Neurosurgery. He is the author of more than 300 articles and book chapters and has written a book on radiosurgery. He is a member of numerous professional organizations. Most notably, he is a Past-President of the Congress of Neurological Surgeons, Past President of the Florida Neurosurgical Society, and Past President of the International Stereotactic Radiosurgery Society. He was the Founding Editor of Neurosurgery On Call, the Internet homepage of organized neurosurgery. He was a member of the Shands Hospital Board of Directors for two terms. Dr. Friedman led the Level I Trauma task force which resulted in the establishment of a trauma center at UF Health. He was also the first ACGME Designated Institutional Official (DIO) at UF. In 1986, Dr. Friedman began collaborative work with Dr. Frank Bova, which led to the development of the University of Florida radiosurgery system. This system was subsequently patented by the University of Florida and licensed to Philips, then Sofamor-Danek, then Varian. The commercial version of the system has become one of the most popular radiosurgical systems worldwide. Drs. Friedman and Bova received the 1990 UF College of Medicine Clinical Research Prize in recognition of this accomplishment. Dr. Friedman is the leader of a multidisciplinary radiosurgery team which has treated over 4500 patients, published more than120 papers and chapters, produced many international meetings, and educated hundreds of visiting physicians. Drs. Bova and Friedman received NIH R01 funding to support their continuing research efforts. Dr. Friedman is the Director of the Preston Wells Center for Brain Tumor Therapy at the University of Florida. During his tenure as Chair of the Department of Neurosurgery he has grown the department’s endowed funds to greater than $45 million, much of which is focused on finding a cure for malignant brain tumors. In recent years, Dr. Friedman has also worked hard to elevate the quality metrics of the department and has become a frequent national neurosurgical speaker on quality improvement. After almost 20 years in the job, Dr. Friedman stepped down as Chair on July 1, 2018 but continues to run a very busy neurosurgical practice. In his spare time he loves travel, hiking, reading, Civil War history, cooking, and time with friends and family.

Accomplishments

UF COM Wall of Fame
2018 · University of Florida
UF COM Lifetime Achievement Award
2016 · University of Florida
America’s Top Doctors
2003-2007 · Book Citation
Elected Fellow
2003 · American Institute for Medical and Biological Engineering
Lecturer
2003 · Florida Frontiers
Fabrikant Award, for outstanding contributions to the field of radiosurgery
2001 · International Stereotactic Radiosurgery Society
Honorary membership
1999 · Mexican Neurosurgical Society
Honorary membership
1994 · Spanish Radiosurgical Society
The Best Doctors in America
1992-2007 · Book Citation
One of 400 Best Cancer Specialists in America
1992 · Good Housekeeping (10/92)
Clinical Faculty Research Award
1990 · UF College of Medicine
Resident Award
1980 · Southern Neurosurgical Society
Department of Surgery Award
1976 · Ohio State University
Alpha Omega Alpha
1975 · Honor Medical Society
Maurice B. Rusoff Award
1975 · Excellence in Medicine
Phi Beta Kappa
1973 · Honor Society
National Merit Scholarship
1970 · Scholarship

Board Certifications

  • Neurological Surgery
    American Board of Neurological Surgery

Clinical Profile

Specialties
  • Neurosurgery
Areas of Interest
  • Acoustic neuroma
  • Brain surgery
  • Brain tumor – primary – adults
  • Cerebral arteriovenous malformation
  • Hemifacial spasm
  • Meningioma
  • Metastatic brain tumor
  • Spinal Cord Tumors
  • Stereotactic radiosurgery
  • Trigeminal neuralgia

Research Profile

In 1986, Friedman began collaborative work with Francis J. Bova, Ph.D., which led to the development of the patented UF radiosurgery system. The system, known as LINAC Scalpel, assists with localizing, planning and treating intracranial tumors using computer software and a specially designed linear accelerator. The LINAC Scalpel has become one of the most popular commercial radiosurgery systems worldwide and has improved the accuracy of high-dose radiation delivered to brain tumors, with very little of the dose reaching normal brain structures. Friedman and Bova received the 1990 UF College of Medicine Clinical Research Prize in recognition of this accomplishment. Friedman is the leader of a multidisciplinary radiosurgery team, which has treated more than 4600 patients, published more than 175 papers and chapters, produced many international meetings and educated hundreds of visiting physicians.

Areas of Interest
  • Radiosurgery

Publications

2018
A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence.
Cell reports. 23(2):637-651 [DOI] 10.1016/j.celrep.2018.03.107. [PMID] 29642018.
2018
Long-term Outcomes After Radiosurgery for Temporal Bone Paragangliomas.
American journal of clinical oncology. 41(3):223-226 [DOI] 10.1097/COC.0000000000000255. [PMID] 26650779.
2016
Obituary: Albert Loren Rhoton Jr., MD, 1932-2016.
Journal of neurosurgery. 125(1):1-3 [DOI] 10.3171/2016.3.JNS16524. [PMID] 27128591.
2016
Long-term Outcome After Fractionated Radiotherapy for Pituitary Adenoma: The Curse of the Secretory Tumor.
American journal of clinical oncology. 39(1):49-54 [DOI] 10.1097/COC.0000000000000014. [PMID] 25007040.
2015
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
The New England journal of medicine. 372(26):2481-98 [DOI] 10.1056/NEJMoa1402121. [PMID] 26061751.
2015
Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs.
Veterinary and comparative oncology. 13(4):409-23 [DOI] 10.1111/vco.12056. [PMID] 24007303.
2014
Follow-up on a national survey: american neurosurgery resident opinions on the 2011 accreditation council for graduate medical education-implemented duty hours.
World neurosurgery. 81(1):15-21 [DOI] 10.1016/j.wneu.2013.08.015. [PMID] 23954736.
2014
Intracranial arteriovenous malformation in a college football player and return-to-play considerations.
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine. 24(6):e62-4 [DOI] 10.1097/JSM.0000000000000058. [PMID] 24389627.
2014
Readmissions in neurosurgery: a qualitative inquiry.
World neurosurgery. 82(3-4):376-9 [DOI] 10.1016/j.wneu.2014.02.028. [PMID] 24560710.
2014
The accuracy of predicting survival in individual patients with cancer.
Journal of neurosurgery. 120(1):24-30 [DOI] 10.3171/2013.9.JNS13788. [PMID] 24160479.
2014
The risk of malignancy anywhere in the body after linear accelerator (LINAC) stereotactic radiosurgery.
Stereotactic and functional neurosurgery. 92(5):323-33 [DOI] 10.1159/000365225. [PMID] 25277349.
2014
The science of medical decision making: neurosurgery, errors, and personal cognitive strategies for improving quality of care.
World neurosurgery. 82(1-2):e21-9 [DOI] 10.1016/j.wneu.2014.03.030. [PMID] 24650488.
2013
The somatic genomic landscape of glioblastoma.
Cell. 155(2):462-77 [DOI] 10.1016/j.cell.2013.09.034. [PMID] 24120142.
2013
Stereotactic radiosurgery of intracranial arteriovenous malformations.
Neurosurgery clinics of North America. 24(4):561-74 [DOI] 10.1016/j.nec.2013.05.002. [PMID] 24093574.
2013
Mixed-reality simulation for neurosurgical procedures.
Neurosurgery. 73 Suppl 1:138-45 [DOI] 10.1227/NEU.0000000000000113. [PMID] 24051877.
2013
Radiation therapy for optic nerve sheath meningioma.
Practical radiation oncology. 3(3):223-228 [DOI] 10.1016/j.prro.2012.06.010. [PMID] 24674368.
2013
Magnetic resonance imaging assessment of cerebral arteriovenous malformation obliteration after stereotactic radiosurgery.
Neurosurgery. 73(5):761-6 [DOI] 10.1227/NEU.0000000000000086. [PMID] 23863762.
2013
Expanding indications for stereotactic radiosurgery in the treatment of brain metastases.
Neurosurgery. 60 Suppl 1:9-12 [DOI] 10.1227/01.neu.0000430329.25516.94. [PMID] 23839345.
2013
Decreasing ventricular infections through the use of a ventriculostomy placement bundle: experience at a single institution.
Journal of neurosurgery. 118(3):514-20 [DOI] 10.3171/2012.11.JNS121336. [PMID] 23259820.
2012
A recommendation for training in stereotactic radiosurgery for US neurosurgery residents.
Journal of neurosurgery. 117 Suppl:2-4 [DOI] 10.3171/2012.6.GKS12838. [PMID] 23205781.
2012
An observational study of hospital paging practices and workflow interruption among on-call junior neurological surgery residents.
Journal of graduate medical education. 4(4):467-71 [DOI] 10.4300/JGME-D-11-00306.1. [PMID] 24294423.
2012
An observational study of junior neurosurgery resident call at a large teaching hospital.
Journal of graduate medical education. 4(1) [DOI] 10.4300/JGME-D-11-00251.1. [PMID] 23451323.
2012
Radiographic response of brain metastasis after linear accelerator radiosurgery.
Stereotactic and functional neurosurgery. 90(2):69-78 [DOI] 10.1159/000334669. [PMID] 22286386.
2012
Reducing ventriculostomy-related infections to near zero: the eliminating ventriculostomy infection study.
Joint Commission journal on quality and patient safety. 38(10):459-64 [PMID] 23130392.
View on: PubMed
2012
Repeat radiosurgery for intracranial arteriovenous malformations.
Neurosurgery. 70(1):150-4; discussion 154 [DOI] 10.1227/NEU.0b013e31822c5740. [PMID] 21743357.
2012
Results of a national neurosurgery resident survey on duty hour regulations.
Clinical neurosurgery. 59:105-6 [PMID] 22960521.
View on: PubMed
2011
Spontaneous intracranial hypotension: dilemmas in diagnosis.
Neurosurgery. 69(1):4-14; discussion 14 [DOI] 10.1227/NEU.0b013e3182134399. [PMID] 21368701.
2011
Results of a national neurosurgery resident survey on duty hour regulations.
Neurosurgery. 69(6):1162-70 [DOI] 10.1227/NEU.0b013e3182245989. [PMID] 21606883.
2011
Radiosurgery for arteriovenous malformations.
Neurological research. 33(8):803-19 [DOI] 10.1179/1743132811Y.0000000043. [PMID] 22004703.
2011
Disseminated intravascular coagulation during resection of a meningioma: case report.
Neurosurgery. 68(4):E1165-9; discussion E1169 [DOI] 10.1227/NEU.0b013e31820a181a. [PMID] 21242833.
2011
Albert L. Rhoton, Jr., M.D.
World neurosurgery. 75(2):188-91; discussion 192 [DOI] 10.1016/j.wneu.2011.02.014. [PMID] 21492690.
2011
Linear accelerator radiosurgery for nonvestibular schwannomas.
Neurosurgery. 68(4):974-84; discussion 984 [DOI] 10.1227/NEU.0b013e318208f3a1. [PMID] 21221035.
2010
Enhancing competence in graduates through a transition to practice program in neurological surgery.
Clinical neurosurgery. 57:141-4 [PMID] 21280507.
View on: PubMed
2010
Evaluation of a transition to practice program for neurosurgery residents: creating a safe transition from resident to independent practitioner.
Journal of graduate medical education. 2(3):366-72 [DOI] 10.4300/JGME-D-10-00078.1. [PMID] 21976085.
2010
Residency training at a crossroads: duty-hour standards 2010.
Annals of internal medicine. 153(12):826-8 [DOI] 10.7326/0003-4819-153-12-201012210-00287. [PMID] 20956679.
2009
Validation of the radiosurgery-based arteriovenous malformation score in a large linear accelerator radiosurgery experience.
Journal of neurosurgery. 111(4):832-9 [DOI] 10.3171/2009.4.JNS081532. [PMID] 19445567.
2009
Trigeminal neuralgia. A debilitating pain syndrome.
Advance for nurse practitioners. 17(3):51-2 [PMID] 19999437.
View on: PubMed
2009
The surgical treatment of trigeminal neuralgia: overview and experience at the University of Florida.
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. 41(4):211-4 quiz 215 [PMID] 19678507.
View on: PubMed
2009
The Surgical Treatment of Trigeminal Neuralgia: Overview and Experience At the University of Florida
Journal of Neuroscience Nursing. 41:211-214
2009
Rapid fabrication of custom patient biopsy guides.
Journal of applied clinical medical physics. 10(4) [PMID] 19918219.
View on: PubMed
2009
Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery.
Neurosurgical focus. 27(3) [DOI] 10.3171/2009.7.FOCUS09116. [PMID] 19722815.
2009
Outcomes of Who Grade I Meningiomas Receiving Radiotherapy Alone Or After Subtotal Resection
International Journal of Radiation Oncology Biology Physics. 75
2009
Nucleus caudalis dorsal root entry zone lesions: a clinical-radiographic case report.
Stereotactic and functional neurosurgery. 87(5):314-21 [DOI] 10.1159/000235803. [PMID] 19713731.
2009
Linear accelerator radiosurgery for cavernous sinus meningiomas.
Stereotactic and functional neurosurgery. 87(2):120-7 [DOI] 10.1159/000204910. [PMID] 19246961.
2009
Hyponatremia in neurosurgical patients: clinical guidelines development.
Neurosurgery. 65(5):925-35; discussion 935 [DOI] 10.1227/01.NEU.0000358954.62182.B3. [PMID] 19834406.
2009
Rapid Fabrication of Custom Patient Biopsy Guides
. 10:260-272
2008
Can standard magnetic resonance imaging reliably distinguish recurrent tumor from radiation necrosis after radiosurgery for brain metastases? A radiographic-pathological study.
Neurosurgery. 63(5):898-903; discussion 904 [DOI] 10.1227/01.NEU.0000333263.31870.31. [PMID] 19005380.
2008
Do Brain Tumor Self-Rated Karnofsky Peformance Status Scores Correlate With Physician-Rated Scores?
Neuro-Oncology. 10
2008
Linear accelerator radiosurgery for vestibular schwannomas.
Progress in neurological surgery. 21:228-237 [DOI] 10.1159/000157171. [PMID] 18810224.
2008
Linear accelerator stereotactic radiosurgery for metastatic brain tumors: 17 years of experience at the University of Florida.
Neurosurgery. 62(5):1018-31; discussion 1031 [DOI] 10.1227/01.neu.0000325863.91584.09. [PMID] 18580799.
2007
Trilogy image-guided stereotactic radiosurgery.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 32(2):121-33 [PMID] 17472891.
View on: PubMed
2007
Optical tracking technology in stereotactic radiation therapy.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 32(2):111-20 [PMID] 17472890.
View on: PubMed
2007
Stereotactic radiosurgery–an organized neurosurgery-sanctioned definition.
Journal of neurosurgery. 106(1):1-5 [PMID] 17240553.
View on: PubMed
2007
Hyperbaric oxygen in the treatment of a radiosurgical complication: technical case report.
Neurosurgery. 60(3) [PMID] 17327770.
View on: PubMed
2007
Effect of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma.
Journal of neurosurgery. 107(5):913-6 [PMID] 17977260.
View on: PubMed
2007
Radiosurgery in patients with bilateral vestibular schwannomas.
Stereotactic and functional neurosurgery. 85(6):273-8 [PMID] 17709979.
View on: PubMed
2006
Linear accelerator radiosurgery for vestibular schwannomas.
Journal of neurosurgery. 105(5):657-61 [PMID] 17121123.
View on: PubMed
2006
Pontine atypical neurocytoma: case report.
Neurosurgery. 58(5) [PMID] 16639306.
View on: PubMed
2006
An investigation of the potential of rapid prototyping technology for image guided surgery.
Journal of applied clinical medical physics. 7(4):81-98 [PMID] 17533357.
View on: PubMed
2005
A geometrically based method of step and shoot stereotactic radiosurgery with a miniature multileaf collimator.
Physics in medicine and biology. 50(14):3263-76 [PMID] 16177508.
View on: PubMed
2005
Linear accelerator surgery for meningiomas.
Journal of neurosurgery. 103(2):206-9 [PMID] 16175847.
View on: PubMed
2005
Radiosurgery in the treatment of malignant gliomas: the University of Florida experience.
Neurosurgery. 57(3):512-7; discussion 512 [PMID] 16145530.
View on: PubMed
2005
Radiotherapy and radiosurgery for benign neurofibromas.
American journal of clinical oncology. 28(3):317-20 [PMID] 15923807.
View on: PubMed
2004
Self-awareness of deficits in Parkinson disease.
The Clinical neuropsychologist. 18(3):352-61 [PMID] 15739807.
View on: PubMed
2004
Resident duty hours in American neurosurgery.
Neurosurgery. 54(4):925-31; discussion 931 [PMID] 15046659.
View on: PubMed
2004
Radiosurgery and radiotherapy: observations and clarifications.
Journal of neurosurgery. 101(4):585-9 [PMID] 15481710.
View on: PubMed
2004
Part III: Radiosurgery in the treatment of brain metastases.
Clinical neurosurgery. 51:264-70 [PMID] 15571152.
View on: PubMed
2004
Management of acoustic schwannoma.
American journal of otolaryngology. 25(1):38-47 [PMID] 15011205.
View on: PubMed
2004
Magnetic resonance imaging of the posterior columns in vitamin B12 deficiency.
Archives of neurology. 61(8) [PMID] 15313854.
View on: PubMed
2004
Linear accelerator radiosurgery in the treatment of brain metastases.
Neurosurgery. 55(5):1076-85 [PMID] 15509314.
View on: PubMed
2004
Do the morphological characteristics of arteriovenous malformations affect the results of radiosurgery?
Journal of neurosurgery. 101(3):393-401 [PMID] 15352595.
View on: PubMed
2004
Management of benign skull base meningiomas: a review.
Skull base : official journal of North American Skull Base Society … [et al.]. 14(1):53-60; discussion 61 [PMID] 16145585.
View on: PubMed
2003
Oligodendroglioma: does deferring treatment compromise outcome?
American journal of clinical oncology. 26(3):e60-6 [PMID] 12796617.
View on: PubMed
2003
Salvage retreatment after failure of radiosurgery in patients with arteriovenous malformations.
Journal of neurosurgery. 98(2):337-41 [PMID] 12593620.
View on: PubMed
2003
Radiotherapy alone or after subtotal resection for benign skull base meningiomas.
Cancer. 98(7):1473-82 [PMID] 14508835.
View on: PubMed
2003
Mental object rotation in Parkinson’s disease.
Journal of the International Neuropsychological Society : JINS. 9(7):1078-87 [PMID] 14738288.
View on: PubMed
2003
Ultrasound-guided extracranial radiosurgery: technique and application.
International journal of radiation oncology, biology, physics. 55(4):1092-101 [PMID] 12605989.
View on: PubMed
2003
Clinical controversy: how do you manage germ cell tumors of the CNS?
Surgical neurology. 60(1):5-7 [PMID] 12864995.
View on: PubMed
2003
Linear accelerator-based radiosurgery for vestibular schwannoma.
Neurosurgical focus. 14(5) [PMID] 15669813.
View on: PubMed
2003
A simple and reliable index for scoring rival stereotactic radiosurgery plans.
International journal of radiation oncology, biology, physics. 57(4):1141-9 [PMID] 14575847.
View on: PubMed
2003
Routine use of postoperative ICU care for elective craniotomy: a cost-benefit analysis.
Surgical neurology. 60(6):483-9; dicussion 489 [PMID] 14670660.
View on: PubMed
2003
Analysis of factors predictive of success or complications in arteriovenous malformation radiosurgery.
Neurosurgery. 52(2):296-307; discussion 307 [PMID] 12535357.
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2002
Radiosurgery for paraganglioma of the temporal bone.
Head & neck. 24(4):384-9 [PMID] 11933180.
View on: PubMed
2002
Temporary ventricular drainage and emergency radiotherapy in the management of hydrocephalus associated with germinoma.
Journal of neurosurgery. 96(6):1020-2 [PMID] 12066901.
View on: PubMed
2001
Stereotactic biopsy aided by a computer graphics workstation: experience with 200 consecutive cases.
Surgical neurology. 56(6):366-71; discussion 371 [PMID] 11755966.
View on: PubMed
2001
Optically guided intensity modulated radiotherapy.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 61(1):33-44 [PMID] 11578726.
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2001
Isotropic beam bouquets for shaped beam linear accelerator radiosurgery.
Physics in medicine and biology. 46(10):2571-86 [PMID] 11686276.
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2001
Initial clinical experience with frameless stereotactic radiosurgery: analysis of accuracy and feasibility.
International journal of radiation oncology, biology, physics. 51(4):1152-8 [PMID] 11704340.
View on: PubMed
2001
Radiosurgery using a stereotactic headframe system for irradiation of brain tumors in dogs.
Journal of the American Veterinary Medical Association. 219(11):1562-7, 1550 [PMID] 11759994.
View on: PubMed
2001
Calibration of three-dimensional ultrasound images for image-guided radiation therapy.
Physics in medicine and biology. 46(2):559-77 [PMID] 11229734.
View on: PubMed
2001
Analysis of risk factors associated with radiosurgery for vestibular schwannoma.
Journal of neurosurgery. 95(3):440-9 [PMID] 11565866.
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2001
A neuropsychological outcome study of a child’s left pericallosal arteriovenous malformation with occult fornix lesion.
Neurocase. 7(6):503-13 [PMID] 11788742.
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2001
Emotional conversations in Parkinson’s disease.
Neurology. 56(2):159-65 [PMID] 11160949.
View on: PubMed
2000
A high-precision system for conformal intracranial radiotherapy.
International journal of radiation oncology, biology, physics. 47(4):1137-43 [PMID] 10863087.
View on: PubMed
2000
Calculation of cranial nerve complication probability for acoustic neuroma radiosurgery.
International journal of radiation oncology, biology, physics. 47(3):597-602 [PMID] 10837941.
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2000
Changes in vocal intensity in Parkinson’s disease following pallidotomy surgery.
Journal of voice : official journal of the Voice Foundation. 14(4):589-606 [PMID] 11130116.
View on: PubMed
2000
Cognitive and vestibulo-proprioceptive components of spatial ability in Parkinson’s disease.
Neuropsychologia. 38(6):757-67 [PMID] 10689051.
View on: PubMed
2000
Image localization for frameless stereotactic radiotherapy.
International journal of radiation oncology, biology, physics. 46(5):1291-9 [PMID] 10725643.
View on: PubMed
2000
Linear accelerator radiosurgery for skull base tumors.
Neurosurgery clinics of North America. 11(4):667-80 [PMID] 11082177.
View on: PubMed
2000
Linear accelerator radiosurgery in the management of brain tumours.
Annals of medicine. 32(1):64-80 [PMID] 10711580.
View on: PubMed
2000
Presidential address: “What is the meaning of life?”.
Clinical neurosurgery. 46:1-11 [PMID] 10944665.
View on: PubMed
2000
RTOG 90-05: the real conclusion.
International journal of radiation oncology, biology, physics. 47(2):269-71 [PMID] 10802348.
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2000
Stereotactic radiosurgery: techniques and clinical applications.
Surgical oncology clinics of North America. 9(3):469-87, viii [PMID] 10853137.
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2000
A geometrically based method for automated radiosurgery planning.
International journal of radiation oncology, biology, physics. 48(5):1599-611 [PMID] 11121667.
View on: PubMed
1999
A comparison of 3-D data correlation methods for fractionated stereotactic radiotherapy.
International journal of radiation oncology, biology, physics. 43(3):663-70 [PMID] 10078654.
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1999
Analytic characterization of linear accelerator radiosurgery dose distributions for fast optimization.
Physics in medicine and biology. 44(11):2777-87 [PMID] 10588284.
View on: PubMed
1999
Linac radiosurgery for benign meningiomas.
International journal of radiation oncology, biology, physics. 43(2):321-7 [PMID] 10030256.
View on: PubMed
1999
Linear accelerator radiosurgery for nonacoustic schwannomas.
International journal of radiation oncology, biology, physics. 43(3):545-8 [PMID] 10078635.
View on: PubMed
1999
Linear accelerator radiosurgery in brain tumor management.
Neurosurgery clinics of North America. 10(2):203-42 [PMID] 10099089.
View on: PubMed
1999
Radiosurgery versus surgery for arteriovenous malformations: the case for radiosurgery.
Clinical neurosurgery. 45:18-20 [PMID] 10461496.
View on: PubMed
1999
Voice and speech characteristics of persons with Parkinson’s disease pre- and post-pallidotomy surgery: preliminary findings.
Journal of speech, language, and hearing research : JSLHR. 42(5):1176-94 [PMID] 10515514.
View on: PubMed
1999
Image registration of BANG gel dose maps for quantitative dosimetry verification.
International journal of radiation oncology, biology, physics. 43(5):1135-41 [PMID] 10192365.
View on: PubMed
1998
Treatment planning optimization for linear accelerator radiosurgery.
International journal of radiation oncology, biology, physics. 41(1):183-97 [PMID] 9588933.
View on: PubMed
1998
The radiobiology of radiosurgery and stereotactic radiotherapy.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 23(3):201-7 [PMID] 9783273.
View on: PubMed
1998
The effect of LINAC stereotactic radiosurgery on epilepsy associated with arteriovenous malformations.
Stereotactic and functional neurosurgery. 71(2):51-61 [PMID] 10087469.
View on: PubMed
1998
Preliminary experience with frameless stereotactic radiotherapy.
International journal of radiation oncology, biology, physics. 42(3):591-9 [PMID] 9806519.
View on: PubMed
1998
Potential clinical efficacy of intensity-modulated conformal therapy.
International journal of radiation oncology, biology, physics. 40(2):483-95 [PMID] 9457839.
View on: PubMed
1998
Linac scalpel radiosurgery at the University of Florida.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 23(3):177-85 [PMID] 9783271.
View on: PubMed
1998
IRLED-based patient localization for linac radiosurgery.
International journal of radiation oncology, biology, physics. 41(2):433-9 [PMID] 9607362.
View on: PubMed
1998
Calcified cystic lesions in a patient with epilepsy and progressive dementia.
Journal of neuroimaging : official journal of the American Society of Neuroimaging. 8(2):97-102 [PMID] 9557148.
View on: PubMed
1998
Analysis of treatment failure after radiosurgery for arteriovenous malformations.
Journal of neurosurgery. 89(1):104-10 [PMID] 9647180.
View on: PubMed
1998
Optic-guided stereotactic radiotherapy.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 23(3):221-8 [PMID] 9783275.
View on: PubMed
1997
The University of Florida frameless high-precision stereotactic radiotherapy system.
International journal of radiation oncology, biology, physics. 38(4):875-82 [PMID] 9240657.
View on: PubMed
1997
Stereotactic pallidotomy lengthens the transcranial magnetic cortical stimulation silent period in Parkinson’s disease.
Neurology. 49(5):1278-83 [PMID] 9371908.
View on: PubMed
1997
Benign meningiomas: primary treatment selection affects survival.
International journal of radiation oncology, biology, physics. 39(2):427-36 [PMID] 9308947.
View on: PubMed
1997
Invasive monitoring of limbic epilepsy using stereotactic depth and subdural strip electrodes: surgical technique.
Surgical neurology. 48(1):74-9 [PMID] 9199690.
View on: PubMed
1997
Radiotherapy for pituitary adenoma: long-term outcome and sequelae.
International journal of radiation oncology, biology, physics. 39(2):437-44 [PMID] 9308948.
View on: PubMed
1996
A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis.
International journal of radiation oncology, biology, physics. 35(1):27-35 [PMID] 8641923.
View on: PubMed
1996
Accelerated hyperfractionated radiotherapy for malignant gliomas.
International journal of radiation oncology, biology, physics. 34(4):785-92 [PMID] 8598354.
View on: PubMed
1996
Preliminary results of linear accelerator radiosurgery for acoustic schwannomas.
Journal of neurosurgery. 85(6):1013-9 [PMID] 8929489.
View on: PubMed
1996
Prospective, multicenter study of spinal cord stimulation for relief of chronic back and extremity pain.
Spine. 21(23):2786-94 [PMID] 8979327.
View on: PubMed
1996
The lazaroid U74389G protects normal brain from stereotactic radiosurgery-induced radiation injury.
International journal of radiation oncology, biology, physics. 34(3):591-7 [PMID] 8621283.
View on: PubMed
1996
The risk of hemorrhage after radiosurgery for arteriovenous malformations.
Journal of neurosurgery. 84(6):912-9 [PMID] 8847584.
View on: PubMed
1995
Radiosurgery in the initial management of malignant gliomas: survival comparison with the RTOG recursive partitioning analysis. Radiation Therapy Oncology Group.
International journal of radiation oncology, biology, physics. 32(4):931-41 [PMID] 7607967.
View on: PubMed
1995
Treatment selection factors for stereotactic radiosurgery of intracranial metastases.
International journal of radiation oncology, biology, physics. 32(4):1161-6 [PMID] 7607938.
View on: PubMed
1995
Stereotactic biopsy of brainstem mass lesions.
Surgical neurology. 43(6):563-7; discussion 567 [PMID] 7482235.
View on: PubMed
1995
Radiosurgery for arteriovenous malformations.
Clinical neurosurgery. 42:328-47 [PMID] 8846601.
View on: PubMed
1995
Linac radiosurgery for high-grade gliomas: the University of Florida experience.
International journal of radiation oncology, biology, physics. 32(1):205-10 [PMID] 7721617.
View on: PubMed
1995
Linac radiosurgery for locally recurrent nasopharyngeal carcinoma: rationale and technique.
Head & neck. 17(1):14-9 [PMID] 7883544.
View on: PubMed
1995
Intracranial arteriovenous malformations: quantitative analysis of magnitude contrast MR angiography versus gradient-echo MR imaging versus conventional angiography.
Radiology. 196(1):187-93 [PMID] 7784565.
View on: PubMed
1995
Linear accelerator radiosurgery for arteriovenous malformations: the relationship of size to outcome.
Journal of neurosurgery. 82(2):180-9 [PMID] 7815144.
View on: PubMed
1994
Linear accelerator-based stereotactic radiosurgery for acoustic schwannomas.
International journal of radiation oncology, biology, physics. 28(4):803-10 [PMID] 8138432.
View on: PubMed
1994
Radiosurgical treatment of a hemangioblastoma: case report.
Neurosurgery. 34(2):353-5; discussion 355 [PMID] 8177399.
View on: PubMed
1994
Temporal characteristics of radiosurgical lesions in an animal model.
Journal of neurosurgery. 80(6):1046-55 [PMID] 8189260.
View on: PubMed
1993
Delayed computed tomography contrast enhancement patterns in biopsy proven cases.
Neurosurgery. 32(4):560-9 [PMID] 8474647.
View on: PubMed
1993
LINAC radiosurgery: an animal model.
Journal of neurosurgery. 78(4):638-44 [PMID] 8450338.
View on: PubMed
1993
Modifications based on computed tomographic imaging in planning the radiosurgical treatment of arteriovenous malformations.
Neurosurgery. 33(4):588-95; discussion 595 [PMID] 8232797.
View on: PubMed
1993
Radiosurgery for arteriovenous malformations.
Clinical neurosurgery. 40:446-64 [PMID] 8111995.
View on: PubMed
1993
Successful radiosurgical treatment of a dural arteriovenous malformation: case report.
Neurosurgery. 33(1):139-41; discussion 141 [PMID] 8355831.
View on: PubMed
1992
The role of stereotactic technology in the management of intracerebral hemorrhage.
Neurosurgery clinics of North America. 3(3):685-702 [PMID] 1633489.
View on: PubMed
1992
Stereotactic radiosurgery.
Medical progress through technology. 18(4):239-51 [PMID] 1339946.
View on: PubMed
1992
Linear accelerator radiosurgery.
Clinical neurosurgery. 38:445-71 [PMID] 1537197.
View on: PubMed
1992
Linear accelerator radiosurgery for arteriovenous malformations.
Journal of neurosurgery. 77(6):832-41 [PMID] 1432123.
View on: PubMed
1992
Acute bilateral ophthalmoplegia secondary to cavernous sinus metastasis: a case report.
Neurosurgery. 31(4):783-6; discussion 786 [PMID] 1407469.
View on: PubMed
1992
Limitations of angiographic target localization in planning radiosurgical treatment.
Neurosurgery. 30(4):619-23; discussion 623 [PMID] 1584365.
View on: PubMed
1992
[Radiosurgery].
Harefuah. 123(3-4):119-22 [PMID] 1516861.
View on: PubMed
1992
Linear accelerator radiosurgery at the University of Florida.
Neurosurgery clinics of North America. 3(1):141-66 [PMID] 1633444.
View on: PubMed
1991
The electrophysiology of peripheral nerve injuries.
Neurosurgery clinics of North America. 2(1):43-56 [PMID] 1668265.
View on: PubMed
1991
Spinal cord stimulation: a contemporary series.
Neurosurgery. 28(1):65-70; discussion 70 [PMID] 1704492.
View on: PubMed
1991
Stereotactic suboccipital transcerebellar biopsy under local anesthesia using the Cosman-Roberts-Wells frame. Technical note.
Journal of neurosurgery. 75(3):486-8 [PMID] 1869955.
View on: PubMed
1991
Stereotactic angiography: an inadequate database for radiosurgery?
International journal of radiation oncology, biology, physics. 20(4):891-5 [PMID] 2004968.
View on: PubMed
1991
Rapid determination of thalamic CT-stereotactic coordinates: a method.
Acta neurochirurgica. 110(1-2):77-81 [PMID] 1882723.
View on: PubMed
1991
Anatomic examination of a case of open trigeminal nucleotomy (nucleus caudalis dorsal root entry zone lesions) for facial pain.
Stereotactic and functional neurosurgery. 56(3):166-78 [PMID] 1796221.
View on: PubMed
1991
Monitoring of somatosensory evoked potentials during surgery for middle cerebral artery aneurysms.
Neurosurgery. 29(1):83-8 [PMID] 1870692.
View on: PubMed
1991
A device for experimental radiosurgery.
Stereotactic and functional neurosurgery. 56(4):213-9 [PMID] 1808646.
View on: PubMed
1991
Persistent nidus blood flow in cerebral arteriovenous malformation after stereotactic radiosurgery: MR imaging assessment.
Radiology. 180(3):785-91 [PMID] 1871294.
View on: PubMed
1991
Is it time to use evoked potentials to predict outcome in comatose children and adults?
Critical care medicine. 19(4):518-24 [PMID] 2019138.
View on: PubMed
1990
LINAC radiosurgery.
Neurosurgery clinics of North America. 1(4):991-1008 [PMID] 2136180.
View on: PubMed
1989
The incidence of unexpected pathological findings in an image-guided biopsy series: a review of 100 consecutive cases.
Neurosurgery. 25(2):180-4 [PMID] 2671781.
View on: PubMed
1989
The University of Florida radiosurgery system.
Surgical neurology. 32(5):334-42 [PMID] 2683164.
View on: PubMed
1988
Magnetic resonance imaging in the assessment of medullary compression in achondroplasia.
American journal of diseases of children (1960). 142(9):989-92 [PMID] 3046333.
View on: PubMed
1988
Somatosensory evoked potential monitoring accurately predicts hemi-spinal cord damage: a case report.
Neurosurgery. 22(1 Pt 1):140-2 [PMID] 3344073.
View on: PubMed
1988
Somatosensory evoked potentials in neurosurgery.
Clinical neurosurgery. 34:187-238 [PMID] 3288394.
View on: PubMed
1988
The meningioma controversy: postoperative radiation therapy.
International journal of radiation oncology, biology, physics. 15(2):299-304 [PMID] 3403313.
View on: PubMed
1987
Ulnar neuropathy in a patient with multiple schwannomas of the ulnar nerve.
Surgical neurology. 28(2):153-7 [PMID] 3037712.
View on: PubMed
1987
Thoracic aortic occlusion: somatosensory evoked potential monitoring and neurologic outcome in a canine model.
Surgical neurology. 28(5):351-60 [PMID] 3660205.
View on: PubMed
1987
Somatosensory evoked potentials after sequential extremity stimulation: a new method for improved monitoring accuracy.
Neurosurgery. 21(5):755-8 [PMID] 3696418.
View on: PubMed
1987
Posterior tibial nerve stimulation and spinal SEP’s.
Journal of neurosurgery. 67(2):320-1 [PMID] 3598697.
View on: PubMed
1987
Persistent memory loss following section of the anterior fornix in humans. A historical review.
Surgical neurology. 27(4):361-4 [PMID] 3103247.
View on: PubMed
1987
Interstitial brachytherapy of malignant brain tumors using computed tomography-guided stereotaxis and available imaging software: technical report.
Neurosurgery. 20(1):4-7 [PMID] 3543725.
View on: PubMed
1987
Monitoring of sensory evoked potentials is highly reliable and helpful in the operating room.
Journal of clinical monitoring. 3(1):38-44 [PMID] 3546609.
View on: PubMed
1987
Evoked potential monitoring during aneurysm operation: observations after fifty cases.
Neurosurgery. 20(5):678-87 [PMID] 3601013.
View on: PubMed
1987
Effects of aortic occlusion on regional spinal cord blood flow and somatosensory evoked potentials in sheep.
Neurosurgery. 21(5):668-75 [PMID] 3696400.
View on: PubMed
1987
Observations on the treatment of lumbar disk disease in college football players.
The American journal of sports medicine. 15(1):72-5 [PMID] 3812863.
View on: PubMed
1987
Electrophysiological evaluation of the patient with acute spinal cord injury.
Critical care clinics. 3(3):519-48 [PMID] 3332213.
View on: PubMed
1986
Respiratory-related cortical potentials evoked by inspiratory occlusion in humans.
Journal of applied physiology (Bethesda, Md. : 1985). 60(6):1843-8 [PMID] 3722053.
View on: PubMed
1986
Somatosensory evoked potential monitoring of spinal cord ischemia during aortic operations.
Neurosurgery. 19(1):82-90 [PMID] 3748342.
View on: PubMed
1986
Regeneration in peripheral nerve grafts to the cat spinal cord.
Brain research. 362(1):149-56 [PMID] 3942862.
View on: PubMed
1986
Chemonucleolysis versus open discectomy: the case against chymopapain.
Clinical neurosurgery. 33:385-96 [PMID] 3791808.
View on: PubMed
1986
Effects of induced hypotension during experimental vasospasm: a neurological, electrophysiological, and pathological analysis.
Neurosurgery. 19(1):41-8 [PMID] 3748337.
View on: PubMed
1985
Intraoperative brain-stem auditory evoked potentials during posterior fossa microvascular decompression.
Journal of neurosurgery. 62(4):552-7 [PMID] 3973725.
View on: PubMed
1985
Percutaneous discectomy: an anatomical study.
Neurosurgery. 16(2):141-7 [PMID] 3974824.
View on: PubMed
1985
Somatosensory evoked potentials in hysterical paraplegia.
Surgical neurology. 23(5):502-6 [PMID] 3983806.
View on: PubMed
1984
Automatic artifact rejection during intraoperative recording of somatosensory evoked potentials. Technical note.
Journal of neurosurgery. 61(3):609-11 [PMID] 6747704.
View on: PubMed
1984
CT directed biopsy of intracranial neoplasms: experience with Brown-Roberts-Wells stereotaxic frame.
The Journal of the Florida Medical Association. 71(11):851-5 [PMID] 6399720.
View on: PubMed
1984
Intraoperative electrophysiology in treatment of peripheral nerve injuries.
The Journal of the Florida Medical Association. 71(6):400-3 [PMID] 6544324.
View on: PubMed
1984
Pitfalls in the computed tomographic diagnosis of toruloma.
Surgical neurology. 21(2):113-8 [PMID] 6701746.
View on: PubMed
1983
Percutaneous discectomy: an alternative to chemonucleolysis?
Neurosurgery. 13(5):542-7 [PMID] 6227832.
View on: PubMed
1983
Superficial siderosis: a cause of leptomeningeal enhancement on computed tomography.
Journal of computer assisted tomography. 7(6):1073-6 [PMID] 6630637.
View on: PubMed
1982
Successful treatment of the normal perfusion pressure breakthrough syndrome.
Neurosurgery. 11(5):625-30 [PMID] 7155329.
View on: PubMed
1981
Recurrent inhibition in type-identified motoneurons.
Journal of neurophysiology. 46(6):1349-59 [PMID] 7320748.
View on: PubMed
1981
Rheobase, input resistance, and motor-unit type in medial gastrocnemius motoneurons in the cat.
Journal of neurophysiology. 46(6):1326-38 [PMID] 6275043.
View on: PubMed
1981
Encysted fourth ventricle.
Surgical neurology. 16(2):150-3 [PMID] 6974409.
View on: PubMed
1980
A quantitative assessment of CSF reabsorption in infants with meningomyelocele.
Surgical neurology. 13(1):38-40 [PMID] 7361256.
View on: PubMed
1980
Cervical carotid dissecting aneurysms.
Neurosurgery. 7(3):207-14 [PMID] 7207736.
View on: PubMed
1980
Hydrocephalus in achondroplasia: a possible mechanism.
Neurosurgery. 7(2):150-3 [PMID] 7422111.
View on: PubMed
1980
Percutaneous tunnel ventriculostomy. Summary of 100 procedures.
Journal of neurosurgery. 53(5):662-5 [PMID] 7431075.
View on: PubMed
1979
Cushing’s disease with cyclic hormonogenesis and diabetes insipidus.
Neurosurgery. 5(5):598-603 [PMID] 534067.
View on: PubMed
1979
Ganglioglioma of the medulla oblongata.
Surgical neurology. 12(1):105-8 [PMID] 451854.
View on: PubMed
1977
Posterior compartment syndrome of the thigh with a sciatic palsy.
Journal of neurosurgery. 46(3):369-72 [PMID] 839262.
View on: PubMed

Grants

Jul 2018 ACTIVE
Florida Center for Brain Tumor Research
Role: Principal Investigator
Funding: FL DEPT OF HLTH
Jul 2017 – Jun 2019
FIorida Center for Brain Tumor Research (FCBTR)
Role: Principal Investigator
Funding: ACCELERATE BRAIN CANCER CURE
Jul 2016 – Jun 2018
Florida Center for Brain Tumor Research (FCBTR) Grant for 2016
Role: Principal Investigator
Funding: ACCELERATE BRAIN CANCER CURE
Jul 2016 ACTIVE
MIsc. Donors
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Jul 2015 ACTIVE
ABC2 funding for Florida Center for Brain Tumor Researc
Role: Principal Investigator
Funding: ACCELERATE BRAIN CANCER CURE
Aug 2014 – Dec 2017
Finding the Genes that Predispose to Trigeminal Neuralgia
Role: Principal Investigator
Funding: THE FACIAL PAIN RESEARCH FOU
Jul 2013 ACTIVE
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
Role: Principal Investigator
Funding: FL DEPT OF HLTH
Mar 2013 ACTIVE
Support for brain tumor research
Role: Principal Investigator
Funding: UF FOU
Jun 2012 – Jun 2017
Resident Fatigue as Function of Shift Length
Role: Principal Investigator
Funding: UF FOU
Jul 2011 – Jun 2019
Support for Research in Regenerative Medicine
Role: Principal Investigator
Funding: UF FOU
Feb 2011 – Feb 2019
Thompson Foundation
Role: Principal Investigator
Funding: UF FOU
Feb 2009 ACTIVE
Wells Center for Brain Tumor Therapy
Role: Principal Investigator
Funding: UF FOU

Patents

Issued July 1991
Dosimetric Technique for Stereotactic Radiosurgery
#5,027,818
Issued February 1993
Apparatus for Stereotactic Radiosurgery
#5,189,687
Issued December 1996
Repeat Fixation for Frameless Stereotactic Procedure Medical Method
#5,588,430
Issued April 1997
ImMerge Software
#TXu 793-734
Issued October 1997
O.R.-LOC
#TXu 809-633
Issued September 1999
Marker System & Related Stereotactic Procedure
#5,954,647
Issued May 2002
Ultrasound Guidance of Target Structures For Therapeutic Applications
#6,390,982
Issued April 2003
Computer Controlled Guidance of a Biopsy Needle
#6,546,279
Published October 2003
Frameless Stereotactic Guidance of Medical Procedures
#US-2005-0075649-A1
Issued December 2003
Intensity Modulated Radiation Therapy Planning System
#6,661,872
Issued April 2006
Mask System and Method For Stereotactic Radiotherapy And Image Guided Procedures
#7,024,237
Issued January 2010
Frameless Stereotactic Guidance of Medical Procedures
#7,651,506
Issued April 2010
Preplanning of Guided Medical Procedures
#7,697,969
Issued January 2012
Systems and Methods for Planning Medical Procedures and Designing Medical Devices Based on Anatomical Scan Deformations
#8,099,152
Published June 2014
Simulation System and Methods for Surgical Training
#US-2014-0370475-A1

Education

Residency, Chief – Neurological Surgery
1982 · University of Florida
Residency – Neurological Surgery
1980 · University of Florida
Internship – Surgery
1977 · University of Florida
Medical Degree
1976 · The Ohio State University
Bachelor's Degree – Premedical
1974 · Oberlin College

Teaching Profile

Courses Taught
2018
MDT7650 Elect Top/Neurol Surg

Contact Details

Phones:
Business:
(352) 271-9000
Emails: