Elias Sayour

Elias Sayour, M.D.

Assistant Professor

Business Phone: (352) 273-9000

About Elias Sayour

Elias Sayour, MD, PhD, is an assistant professor in the UF departments of neurosurgery and pediatrics at the University of Florida. He is also a principal investigator of the ribonucleic acid engineering laboratory at the Preston A. Wells, Jr. Center for Brain Tumor Therapy. He received his bachelor’s degree from Fordham University, his medical degree from the University of Buffalo and his doctorate from Duke University.

He completed his residency in pediatrics at Cohen’s Children’s Medical Center in New York and his fellowship at Duke University Medical Center. During his fellowship training, he completed a two-year National Institutes of Health research fellowship in cancer biology and developmental therapeutics. His primary research focus is developing tumor RNA loaded nanocarriers to re-direct host immunity against pediatric brain tumors.

Dr. Sayour is an NIH-funded investigator focused on on developing new nanotech vaccines to reprogram the immune system against cancer cells. He is investigating the use of personalized nanoparticles small enough to deliver essential information to the immune system educating it reject pediatric cancer. Currently his group is investigating the safety and efficacy of this novel vaccine formulation in canines with malignant brain tumors before translation into dedicated human studies.

Dr. Sayour’s work has been nationally recognized by the American Society of Pediatric Hematology-Oncology, National Institutes of Health, and U.S. Department of Defense. He has been the recipient of the Hyundai Hope on Wheels Hope Award, St. Baldrick’s Scholar Award, and the American Brain Tumor Association Discovery Award.

Dr. Sayour is board-certified in general pediatrics and pediatric hematology-oncology.

He has presented his work at several national meetings and is a member of the Children’s Oncology Group, Society of Neuro-Oncology and the American Society of Pediatric Hematology-Oncology.

Board Certifications

  • Pediatrics
    American Board of Pediatrics

Clinical Profile

  • Pediatrics
  • Pediatric Hematology-Oncology
Areas of Interest
  • Brain tumor – children

Research Profile

Areas of Interest
  • Immunotherapeutics for CNS malignancies
  • Pediatric brain tumors


2018 International Journal of Molecular Sciences


December 2019 ACTIVE
Nanoparticles targeting genetic translocations in pediatric brain tumors
HYUNDAI HOPE ON WHEELS · Principal Investigator
July 2019 ACTIVE
Immunotherapeutic targeting of osteosarcoma with nanoparticle vaccines
Rally Foundation · Principal Investigator
July 2019 ACTIVE
Re-programming immunity to target mutations across medulloblastoma subtypes
ST BALDRICKS FOUNDATION · Principal Investigator
January 2019 ACTIVE
Development of personalized RNA loaded nano particles for children with refractory solid tumors.
UF FOU · Principal Investigator
July 2018 ACTIVE
Legacy Foundation
UF FOU · Project Manager
July 2018 ACTIVE
Host Immunomodulatory RNA-nanoparticles targeting malignant canine glioma
UF FOU · Principal Investigator
January 2018 ACTIVE
Development of Personalized RNA Loaded Nanoparticles for Children with Refractory Solid Tumors
H LEE MOFFITT CANCER CTR · Principal Investigator
September 2017 ACTIVE
RNA-nanoparticles targeting H3.3 K27M epitopes in diffuse intrinsic pontine glioma
US ARMY MED RES ACQUISITION · Principal Investigator
September 2017 ACTIVE
UFHCC Triple Negative Breast Cancer (TNBC) Pilot Project Program
July 2017 – December 2019
Immunotherapeutic targeting of osteosarcoma neoantigens
Rally Foundation · Principal Investigator
September 2016 ACTIVE
Harnessing the Immunologic Capacity of RNA-nanoparticle Vaccines Targeting Glioblastoma
NATL INST OF HLTH NCI · Principal Investigator
July 2016 ACTIVE
Re-programming immunity to target mutations across medulloblastoma subtypes
ST BALDRICKS FOUNDATION · Principal Investigator
July 2016 ACTIVE
RNA nanoparticle vaccines targeting malignant canine gliomas
April 2016 – March 2018
Re-programming osteosarcoma immune evasion
UF FOU · Principal Investigator
July 2015 ACTIVE
Florida Academic Cancer Center Alliance Seed Grants
December 2014 – June 2017
Hyundai Hope on Wheels
HYUNDAI HOPE ON WHEELS · Principal Investigator
July 2013 ACTIVE
Florida Center for Brain Tumor Research – Statewide Brain Tumor Registry Program at the McKnight Brain Institute
FL DEPT OF HLTH · Project Manager


Fellowship – Pediatric Hematology/Oncology
2013 · Duke University
Residency – Pediatrics
2010 · Long Island Jewish Medical Center
Medical Degree
2007 · University at Buffalo

Contact Details

(352) 273-9000